My girlfriend always said I was useless, but this is ridiculous: British scientists at the University of Newcastle have coaxed female embryonic stem cells to develop into primitive sperm cells. They'd previously done it with male bone marrow cells, but this new development opens up the door to lesbian couples having children that share genes from both parents.
That same University of Newcastle team is applying for permission to turn female bone marrow into sperm cells, which one lesbian partner could donate to be turned into stem cells, which would then be used to impregnate the other partner. The next step for Prof. Karim Nayernia and team is to encourage the sperm to undergo meiosis to ensure they have enough genetic material to fertilize an egg. Nayernia first flirted with the possibility of deriving sperm from stem cells when he used sperm taken from male embryonic stem cells to fertilize mice to produce seven offspring, six of which survived to adulthood, though they did suffer from side effects.
“I think, in principle, it will be scientifically possible,” Prof Nayernia told New Scientist.
But Prof. Nayernia's methods aren't without technical and ethical detractors.
Dr Robin Lovell-Badge, a stem cell and sex determination expert at the National Institute for Medical Research, Mill Hill, London, doubts it will work: “The presence of two X chromosomes is incompatible with this. Moreover they need genes from the Y chromosome to go through meiosis. So they are at least double-damned.”
Another roadblock might be the ethical restrictions imposed by the government. England, which is generally progressive in this arena, has proposed amending their 1990 Human Fertilisation and Embryology Act to allow use of eggs and sperm grown in a lab, but a clause restricts sperm to come from genetic males and eggs from genetic females.
So if Melissa Etheridge decides to have a few more kids, she's still going to have to hit up David Crosby for some sperm for the time being.
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