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Results tagged “antidepressants” from 60 Second Science

What the media misses about antidepressants

A new meta-analysis of research on modern antidepressants-- some of it unpublished by the drug companies-- suggests that the drugs have little advantage over placebos.

Why then do so many people consider drugs like Prozac to be miracle drugs for depression-- many putting up with serious sexual side effects in order to take them? Are they simply being duped by a placebo effect or avoiding withdrawal symptoms? And how could drugs which are little different from placebo also produce suicidal or even homicidal thoughts in some patients?

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Feeling sad? Get moving!

Yale scientists have discovered that physical exercise enhances the activity of a gene called VGF, which has an antidepressant effect in mice.

Depression afflicts 16 percent of the U.S. population and carries an annual price tag of $83 billion. Pharmaceutical products currently used to treat depression help about 65 percent of patients but require anywhere from weeks to months to kick in.

Unlike common antidepressant drugs, VGF is already present in the brain, making it an attractive target for therapy, says senior author Ronald Duman, professor of psychiatry and pharmacology at Yale School of Medicine.

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